Almanac of Clinical MedicineAlmanac of Clinical MedicineАльманах клинической медицины2072-05052587-9294Moscow Regional Research and Clinical Institute (MONIKI)6610.18786/2072-0505-2015-1-42-45THE PROBLEM OF OBESITYПРОБЛЕМЫ ОЖИРЕНИЯTHE ROLE OF NUTRIGENOMICS IN CORRECTION OF METABOLIC ABNORMALITIESРОЛЬ НУТРИГЕНОМИКИ В КОРРЕКЦИИ МЕТАБОЛИЧЕСКИХ НАРУШЕНИЙMisnikovaI. V.МисниковаИ. В.
Russian Federation

Misnikova Inna Vladimirovna – MD, PhD, Leading Research Fellow, Department of Therapeutic Endocrinology; Professor, Chair of Endocrinology, Postgraduate Training Faculty

* 61/2–9 Shchepkina ul., Moscow, 129110, Russian Federation. Tel.: +7 (495) 688 95 93. E-mail: inna-misnikova@mail.ru

Мисникова Инна Владимировна – доктор медицинских наук, вед. научный сотрудник отделения терапевтической эндокринологии, профессор кафедры эндокринологии факультета усовершенствования врачей

* 129110, г. Москва, ул. Щепкина, 61/2–9, Российская Федерация. Тел.: +7 (495) 688 95 93. E-mail: inna-misnikova@mail.ru

inna-misnikova@mail.ruMoscow Regional Research and Clinical Institute (MONIKI)Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского2012201511Supplement 1Спецвыпуск 142451202201612022016Copyright ©; 2015, Misnikova I.V.Copyright ©; 2015, Мисникова И.В.2015Misnikova I.V.Мисникова И.В.https://creativecommons.org/licenses/by/4.0https://almclinmed.ru/jour/article/view/66

In some patients, diet and increased physical exercise are not effective enough to prevent the development of type 2 diabetes mellitus. At present, a  new approach is proposed to elaborate the diet with consideration of specific need of an individual. Food components can cause changes in metabolism through their influence on activity of certain genes that subsequently influence human proteome and metabolome. It is assumed that nutrients may influence methylation of deoxyribonucleic acid. A number of studies established an interaction between some foods and genes associated with obesity and type 2 diabetes mellitus. Diet recommendations based on presence of certain gene polymorphisms have been developed. The spectrum of gene polymorphisms that is necessary to assess in individuals with metabolic abnormalities or with high risk of their development has been also defined.

У некоторых пациентов диета и  расширение физической активности оказываются недостаточно эффективными мерами в  отношении предотвращения развития сахарного диабета 2-го типа. Сегодня предлагается новый подход к построению диеты с учетом индивидуальных особенностей человека. Компоненты пищи могут вызывать изменения в  метаболизме через воздействие на активность определенных генов, которые, в свою очередь, влияют на протеом и  метаболом человека. Предполагается, что нутриенты могут влиять на процессы метилирования дезоксирибонуклеиновой кислоты. В  ряде исследований установлено взаимодействие между генами, ассоциированными с ожирением и сахарным диабетом 2-го типа, и некоторыми пищевыми продуктами. Разработаны рекомендации по питанию исходя из наличия тех или иных полиморфизмов генов и определен тот спектр полиморфизмов генов, который необходимо исследовать у  лиц с  метаболическими нарушениями или с  высоким риском их развития. 

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