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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Almanac of Clinical Medicine</journal-id><journal-title-group><journal-title xml:lang="en">Almanac of Clinical Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Альманах клинической медицины</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2072-0505</issn><issn publication-format="electronic">2587-9294</issn><publisher><publisher-name xml:lang="en">Moscow Regional Research and Clinical Institute (MONIKI)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">619</article-id><article-id pub-id-type="doi">10.18786/2072-0505-2017-45-5-423-428</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">A clinical case of hereditary thrombophilia in a patient with ulcerative colitis</article-title><trans-title-group xml:lang="ru"><trans-title>Клинический случай наследственной тромбофилии у больной язвенным колитом</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fadeeva</surname><given-names>N. A.</given-names></name><name xml:lang="ru"><surname>Фадеева</surname><given-names>Н. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Fadeeva Nina A. – MD, PhD, Senior Research Fellow, Department of Inflammatory Bowel Diseases.</p><p>86 Shosse Entuziastov, Moscow, 111123, +7 (926) 484 85 90</p></bio><bio xml:lang="ru"><p>Фадеева Нина Александровна – кандидат медицинских наук, ст. научный сотрудник, отделение воспалительных заболеваний кишечника.</p><p>111123, Москва, ш. Энтузиастов, 86, +7 (926) 484 85 90</p></bio><email>chuevana@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Donchenko</surname><given-names>I. A.</given-names></name><name xml:lang="ru"><surname>Донченко</surname><given-names>И. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Donchenko Irina A. – MD, Gastroenterologist, Department of Inflammatory Bowel Diseases.</p><p>86 Shosse Entuziastov, Moscow, 111123</p></bio><bio xml:lang="ru"><p>Донченко Ирина Алексеевна – врач-гастроэнтеролог, отделение воспалительных заболеваний кишечника.</p><p>111123, Москва, ш. Энтузиастов, 86</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Knyazev</surname><given-names>O. V.</given-names></name><name xml:lang="ru"><surname>Князев</surname><given-names>О. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Knyazev Oleg V. – MD, PhD, Head of Department of Inflammatory Bowel Diseases.</p><p>86 Shosse Entuziastov, Moscow, 111123</p></bio><bio xml:lang="ru"><p>Князев Олег Владимирович – доктор медицинских наук, заведующий отделением воспалительных заболеваний кишечника.</p><p>111123, Москва, ш. Энтузиастов, 86</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Lishchinskaya</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Лищинская</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Lishchinskaya Al'bina A. – MD, PhD, Senior Research Fellow, Department of Inflammatory Bowel Diseases.</p><p>86 Shosse Entuziastov, Moscow, 111123</p></bio><bio xml:lang="ru"><p>Лищинская Альбина Александровна – кандидат медицинских наук, ст. научный сотрудник, отделение воспалительных заболеваний кишечника.</p><p>111123, Москва, ш. Энтузиастов, 86</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dudina</surname><given-names>G. A.</given-names></name><name xml:lang="ru"><surname>Дудина</surname><given-names>Г. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dudina Galina A. – MD, PhD, Senior Research Fellow, Department of Oncohematology.</p><p>86 Shosse Entuziastov, Moscow, 111123</p></bio><bio xml:lang="ru"><p>Дудина Галина Анатольевна – кандидат медицинских наук, ст. научный сотрудник, отделение онкогематологии.</p><p>111123, Москва, ш. Энтузиастов, 86</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ruchkina</surname><given-names>I. N.</given-names></name><name xml:lang="ru"><surname>Ручкина</surname><given-names>И. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Ruchkina Irina N. – MD, PhD, Leading Research Fellow, Department of Inflammatory Bowel Diseases.</p><p>86 Shosse Entuziastov, Moscow, 111123</p></bio><bio xml:lang="ru"><p>Ручкина Ирина Николаевна – доктор медицинских наук, вед. научный сотрудник, отделение воспалительных заболеваний кишечника.</p><p>111123, Москва, ш. Энтузиастов, 86</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Subbotin</surname><given-names>V. V.</given-names></name><name xml:lang="ru"><surname>Субботин</surname><given-names>В. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Subbotin Valeriy V. – MD, PhD, Head of Center of Anesthesiology and Intensive Care.</p><p>86 Shosse Entuziastov, Moscow, 111123</p></bio><bio xml:lang="ru"><p>Субботин Валерий Вячеславович – доктор медицинских наук, заведующий центром анестезиологии и реаниматологии.</p><p>111123, Москва, ш. Энтузиастов, 86</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Noskova</surname><given-names>K. K.</given-names></name><name xml:lang="ru"><surname>Носкова</surname><given-names>К. К.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Noskova Karina K. – MD, PhD, Head of Laboratory.</p><p>86 Shosse Entuziastov, Moscow, 111123</p></bio><bio xml:lang="ru"><p>Носкова Карина Кадиевна – кандидат медицинских наук, заведующая лабораторией.</p><p>111123, Москва, ш. Энтузиастов, 86</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Rogozina</surname><given-names>V. A.</given-names></name><name xml:lang="ru"><surname>Рогозина</surname><given-names>В. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Rogozina Vera A. – MD, Endoscopist, Diagnostic Endoscopy Department.</p><p>86 Shosse Entuziastov, Moscow, 111123</p></bio><bio xml:lang="ru"><p>Рогозина Вера Александровна – врач-эндоскопист, отделение диагностической эндоскопии.</p><p>111123, Москва, ш. Энтузиастов, 86</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Parfenov</surname><given-names>A. I.</given-names></name><name xml:lang="ru"><surname>Парфенов</surname><given-names>А. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Parfenov Asfold I. – MD, PhD, Professor, Head of Department of Bowel Diseases.</p><p>86 Shosse Entuziastov, Moscow, 111123</p></bio><bio xml:lang="ru"><p>Парфенов Асфольд Иванович – доктор медицинских наук, профессор, заведующий отделом патологии кишечника.</p><p>111123, Москва, ш. Энтузиастов, 86</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Moscow Clinical Scientific Center, Moscow Healthcare Department</institution></aff><aff><institution xml:lang="ru">ГБУЗ Московский клинический научно-практический центр имени А.С. Логинова Департамента здравоохранения г. Москвы</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-08-15" publication-format="electronic"><day>15</day><month>08</month><year>2017</year></pub-date><volume>45</volume><issue>5</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>423</fpage><lpage>428</lpage><history><date date-type="received" iso-8601-date="2017-12-02"><day>02</day><month>12</month><year>2017</year></date><date date-type="accepted" iso-8601-date="2017-12-02"><day>02</day><month>12</month><year>2017</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, Fadeeva N.A., Donchenko I.A., Knyazev O.V., Lishchinskaya A.A., Dudina G.A., Ruchkina I.N., Subbotin V.V., Noskova K.K., Rogozina V.A., Parfenov A.I.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, Фадеева Н.А., Донченко И.А., Князев О.В., Лищинская А.А., Дудина Г.А., Ручкина И.Н., Субботин В.В., Носкова К.К., Рогозина В.А., Парфенов А.И.</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">Fadeeva N.A., Donchenko I.A., Knyazev O.V., Lishchinskaya A.A., Dudina G.A., Ruchkina I.N., Subbotin V.V., Noskova K.K., Rogozina V.A., Parfenov A.I.</copyright-holder><copyright-holder xml:lang="ru">Фадеева Н.А., Донченко И.А., Князев О.В., Лищинская А.А., Дудина Г.А., Ручкина И.Н., Субботин В.В., Носкова К.К., Рогозина В.А., Парфенов А.И.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://almclinmed.ru/jour/article/view/619">https://almclinmed.ru/jour/article/view/619</self-uri><abstract xml:lang="en"><p>We present  a clinical case of a 24-year old female patient  who was hospitalized  with high active ulcerative  colitis associated  with  latent  hereditary thrombophilia  uncontrolled  due  to  the  exacerbation  of ulcerative colitis and local steroid treatment. The patient  was treated with combination of systemic steroids, adalimumab and anticoagulants. We emphasize  the necessity of the multidisciplinary approach  to her treatment. The clinical case demonstrates the possibility of safe use of anticoagulants to prevent  thromboembolic complications in patients  with ulcerative colitis and high risk of thrombus formation, under careful monitoring of coagulation  parameters and thromboelastography. We discuss the need  in clear guidelines to determine treatment strategy for patients  with inflammatory bowel diseases, coagulopathies and thromboembolic complications.</p></abstract><trans-abstract xml:lang="ru"><p>Приведено  описание  пациентки  24 лет, поступившей в клинику с высокой активностью язвенного колита, ассоциированного с латентной наследственной тромбофилией, активизация которой  была  вызвана  обострением   язвенного колита и применением местной стероидной терапии.  Пациентке назначена  комбинированная терапия системными глюкокортикостероидами, адалимумабом и антикоагулянтами. Подчеркивается необходимость мультидисциплинарного подхода в лечении пациентки. Приведенный  клинический случай демонстрирует, что больным язвенным колитом с высоким риском тромбообразования возможно безопасное назначение антикоагулянтов для профилактики тромбоэмболических осложнений  под постоянным наблюдением, контролем коагулограммы и тромбоэластограммы. Обсуждается необходимость  создания четких рекомендаций по  определению   тактики  лечения   пациентов с воспалительными  заболеваниями кишечника, у которых развиваются коагулопатии и тромбоэмболические осложнения.</p></trans-abstract><kwd-group xml:lang="en"><kwd>ulcerative colitis</kwd><kwd>coagulopathy</kwd><kwd>thrombophilia</kwd><kwd>thromboembolic complications</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>язвенный колит</kwd><kwd>коагулопатия</kwd><kwd>тромбофилия</kwd><kwd>тромбоэмболические осложнения</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1. Algahtani FH, Farag YM, Aljebreen AM, Alazzam NA, Aleem AS, Jabri FF, Rajab MH, Shoukri MM. Thromboembolic events in patients with inflammatory bowel disease. Saudi J Gastroenterol. 2016;22(6):423–7. doi: 10.4103/1319-3767.195558.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>2. Yoshida H, Granger DN. 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