Almanac of Clinical MedicineAlmanac of Clinical Medicine2072-05052587-9294Moscow Regional Research and Clinical Institute (MONIKI)610.18786/2072-0505-2013-28-32-36EFFICIENCY AND SAFETY OF BICARBONATE DIALYTIC SOLUTIONS WITH ACETIC AND LACTIC ACIDS IN CARRYING OUT THE PROGRAM HEMODIALYSIS OF PATIENTS WITH END-STAGE OF CHRONIC RENAL DISEASEMarchenkoT. V.fake@neicon.ruMorozovYu. A.fake@neicon.ruDementievaI. I.fake@neicon.ruVayaL. V.fake@neicon.ruFederal state budgetary institution «Petrovsky National Research Centre of Surgery» under the Russian academy of medical sciences, Moscow150920132832360902201609022016Copyright © 2013, Marchenko T.V., Morozov Y.A., Dementieva I.I., Vaya L.V.2013<p>The data on the influence of bicarbonate dialytic solutions with acetic and lactic acids on the blood acid-base and electrolytic status, parameters of system hemodynamics, and oxidative stress indices in conditions of program hemodialysis are presented in the article.</p>hemodialysisdialysatelactic acidacetic acidгемодиализдиализирующие растворылактатацетат[1.Daugirdas J.T. Second generation logarithmic estimates of single-pool variable volume Kt-V: An analysis of error // J. Am. Soc. Nephrol. 1993. V.4. P.1205-1213.][2.Davenport A., Will E.J., Davison A.M. Hyperlactatemia and metabolic acidosis during hemofiltration using lactate buffered fluids // Nephron. 1991. V.59. P.461-465.][3.Davenport A., Will E., Davison A.M. The effect of lactate-buffered solutions on the acid-base status of patients with renal failure // Nephrol. Dial. Transplant. 1989. V.4. P.800-804.][4.Davenport A., Worth D.P., Will E.J. Hypochloremic alkalo-sis after high flux continuous arterio-venous hemofiltration with dialysis // Lancet. 1988. V.1. P.658.][5.Heering P., Ivens K., Thumer O. et al. The use of different buffers during continuous hemofiltration in critically ill patients with acute renal failure // Int. Care Med. 1999. V.25, No.11. P.1244-1251.][6.Hilton P.J., Taylor J., Forni G., Treacher D.F. Bicarbonate-base haemofiltration in the management of acute renal failure with lactic acidosis // Q. J. Med. 1998. V.91. P.279-283.][7.Kierdorf H., Leue C., Heintz B. et al. Continuous venovenous hemofiltration in acute renal failure: Is a bicarbonate- or lactate-buffered substitution better? // Contrib. Nephrol. 1995. V.116. P.38-47.][8.Levrault J., Ciebiera J-P., Jambou P. et al. Effect of continuous hemofiltration with dialysis on lactate clearance in critically ill patients // Crit. Care Med. 1997. V.25. P.58-62.][9.MacLean A.G., Davenport A., Cox D., Sweny P. Effects of continuous hemofiltration against lactate buffered and lactate free dialyzate in patients with and without liver dysfunction // Kidney Int. 2000. V.58, No.4. P.1765-1772.][10.Manns M., Sigler M.H., Teechan B.P. Continuous renal replacement therapies: an update // Am. J. Kidney Dis. 1998. V.32. P.185-200.][11.Mansell M.A., Morgan S.H., Moore L. et al. Cardiovascular and acid-base effects of acetate and bicarbonate haemo-dialysis // Nephrol. Dial. Transplant. 1987. V.1. P.229-232.][12.Saman S., Opie L.H. Mechanism of reduction of action potential duration of ventricular myocardium by exogenous lactate // J. Mol. Cell. Cardiol. 1984. V.10. P.659-662.][13.Thomas A.N., Guy J.M., Kishen R. et al. Comparison of lactate and bicarbonate buffered haemofiltration fluids: Use in critically ill patients // Nephrol. Dial. Transplant. 1997. V.12. P.1212-1217.][14.Veech R.L. The untoward effects on anions of dialysis fluids // Kidney Int. 1991. V.34. P.587-589.][15.Wright D.A., Forni L.G., Carr L.G. et al. Use of continuous hemofiltration assess of the rate of lactate metabolism in acute renal failure // Clin. Sci. 1996. V.90. P.507-510.]