Almanac of Clinical MedicineAlmanac of Clinical MedicineАльманах клинической медицины2072-05052587-9294Moscow Regional Research and Clinical Institute (MONIKI)55810.18786/2072-0505-2017-45-4-266-279REVIEW ARTICLEОБЗОРClassification, regulation of activity, and genetic polymorphism of matrix metalloproteinases in health and diseaseКлассификация, регуляция активности, генетический полиморфизм матриксных металлопротеиназ в норме и при патологииShadrinaA. S.ШадринаА. С.
Russian Federation

PhD (in Biology), Junior Researcher, Laboratory of Pharmacogenomics

8 Akademika Lavrent'eva prosp., Novosibirsk, 630090, Russian Federation. Tel.: +7 (383) 363 51 71

канд. биол. наук, мл. науч. сотр., лаборатория фармакогеномики

630090, г. Новосибирск, просп. Академика Лаврентьева, 8, Российская Федерация. Тел: +7 (383) 363 51 71

weiner.alexserg@gmail.comPlievaYa. Z.ПлиеваЯ. З.
Russian Federation

PhD Student, Chair of Clinical Biochemistry and Laboratory Diagnostics

20–1 Delegatskaya ul., Moscow, 127473, Russian Federation

соискатель, кафедра клинической биохимии и лабораторной диагностики

127473, г. Москва, ул. Делегатская, 20–1, Российская Федерация

KushlinskiyD. N.КушлинскийД. Н.
Russian Federation

MD, PhD, Surgeon/Gynecologist

24 Kashirskoe shosse, Moscow, 115478, Russian Federation

канд. мед. наук, хирург-гинеколог

115478, г. Москва, Каширское шоссе, 24, Российская Федерация

MorozovA. A.МорозовА. А.
Russian Federation

PhD Student, Chair of Clinical Biochemistry and Laboratory Diagnostics

20–1 Delegatskaya ul., Moscow, 127473, Russian Federation

соискатель, кафедра клинической биохимии и лабораторной диагностики

127473, г. Москва, ул. Делегатская, 20–1, Российская Федерация

FilipenkoM. L.ФилипенкоМ. Л.
Russian Federation

PhD (in Biology), Head of Laboratory of Pharmacogenomics

8 Akademika Lavrent'eva prosp., Novosibirsk, 630090, Russian Federation

канд. биол. наук, руководитель лаборатории фармакогеномики

630090, г. Новосибирск, просп. Академика Лаврентьева, 8, Российская Федерация

ChangV. L.ЧангВ. Л.
Russian Federation

PhD Student, Chair of Clinical Biochemistry and Laboratory Diagnostics

20–1 Delegatskaya ul., Moscow, 127473, Russian Federation

соискатель, кафедра клинической биохимии и лабораторной диагностики

127473, г. Москва, ул. Делегатская, 20–1, Российская Федерация

KushlinskiiN. E.КушлинскийН. Е.
Russian Federation

MD, PhD, Professor, Member-Correspondent of Russian Academy of Sciences, Head of Clinical Biochemistry Laboratory

24 Kashirskoe shosse, Moscow, 115478, Russian Federation

д-р мед. наук, профессор, чл.-корр. РАН, руководитель лаборатории клинической биохимии

115478, г. Москва, Каширское шоссе, 24, Российская Федерация

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of SciencesФГБУН «Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук»Moscow State University of Medicine and Dentistry named after A.I. EvdokimovФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава РоссииN.N. Blokhin Russian Cancer Research CenterФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Минздрава России150620174542662791508201715082017Copyright ©; 2017, Shadrina A.S., Plieva Y.Z., Kushlinskiy D.N., Morozov A.A., Filipenko M.L., Chang V.L., Kushlinskii N.E.Copyright ©; 2017, Шадрина А.С., Плиева Я.З., Кушлинский Д.Н., Морозов А.А., Филипенко М.Л., Чанг В.Л., Кушлинский Н.Е.2017Shadrina A.S., Plieva Y.Z., Kushlinskiy D.N., Morozov A.A., Filipenko M.L., Chang V.L., Kushlinskii N.E.Шадрина А.С., Плиева Я.З., Кушлинский Д.Н., Морозов А.А., Филипенко М.Л., Чанг В.Л., Кушлинский Н.Е.https://creativecommons.org/licenses/by/4.0https://almclinmed.ru/jour/article/view/558

Matrix metalloproteinases (MMPs) are a family of zinc-containing endopeptidases that catalyze the degradation reactions of the extracellular matrix components. In humans, 23 enzymes of this family are known, which are subdivided into 6 groups based on their structure and substrate types: collagenases, gelatinases, stromelysins, matrilizines, MMP membrane type and other MMPs. MMP functions are diverse, and an imbalance of their activity may be one of the etiological factors of various diseases. The review considers classification, regulation of activity and genetic polymorphism of matrix metalloproteinases in health and in various pathological processes in the human body. A list of the most studied polymorphic variants of MMP genes is given, their functional effects are described and the results of associative studies are presented.

Матриксные металлопротеиназы (ММП) – семейство цинксодержащих эндопептидаз, катализирующих реакции деградации компонентов внеклеточного матрикса. У человека известно 23 фермента этого семейства, которые подразделяют на 6 групп с учетом их структуры и типа субстрата: коллагеназы, желатиназы, стромелизины, матрилизины, ММП мембранного типа и остальные ММП. Функции ММП разнообразны, и нарушение баланса их активности может быть одним из этиологических факторов различных заболеваний. В обзоре рассмотрены классификация, регуляция активности и генетический полиморфизм ММП в норме и при различных патологических процессах в организме человека. Приведен перечень наиболее изученных в настоящее время полиморфных вариантов генов MMП, описаны их функциональные эффекты и представлены результаты ассоциативных исследований.

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