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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Almanac of Clinical Medicine</journal-id><journal-title-group><journal-title xml:lang="en">Almanac of Clinical Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Альманах клинической медицины</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2072-0505</issn><issn publication-format="electronic">2587-9294</issn><publisher><publisher-name xml:lang="en">Moscow Regional Research and Clinical Institute (MONIKI)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">5551</article-id><article-id pub-id-type="doi">10.18786/2072-0505-2023-51-011</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Hemorrhage into a somatotropinoma аs a first reason for examination of a patient with previously undiagnosed acromegaly and papillary thyroid cancer</article-title><trans-title-group xml:lang="ru"><trans-title>Кровоизлияние в соматотропиному как первый повод для обследования пациентки с ранее не диагностированными акромегалией и папиллярным раком щитовидной железы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6892-6024</contrib-id><name-alternatives><name xml:lang="en"><surname>Nurullina</surname><given-names>Guzel M.</given-names></name><name xml:lang="ru"><surname>Нуруллина</surname><given-names>Гузель Михайловна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Lecturer, Chair of Faculty Therapy with Courses of Endocrinology and Hematology; Endocrinologist</p></bio><bio xml:lang="ru"><p>канд. мед. наук, преподаватель кафедры факультетской терапии с курсами эндокринологии и гематологии; врач-эндокринолог</p></bio><email>Dalllila@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3992-6420</contrib-id><name-alternatives><name xml:lang="en"><surname>Pushkarev</surname><given-names>Igor N.</given-names></name><name xml:lang="ru"><surname>Пушкарев</surname><given-names>Игорь Николаевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>6<sup>th</sup> Year Student, Faculty of General Medicine</p></bio><bio xml:lang="ru"><p>студент 6-го курса лечебного факультета</p></bio><email>i.push99@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6539-466X</contrib-id><name-alternatives><name xml:lang="en"><surname>Pigarova</surname><given-names>Ekaterina A.</given-names></name><name xml:lang="ru"><surname>Пигарова</surname><given-names>Екатерина Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Director, Institute of Higher and Further Professional Education</p></bio><bio xml:lang="ru"><p>д-р мед. наук, директор Института высшего и дополнительного профессионального образования</p></bio><email>kpigarova@gmail.com</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0662-9232</contrib-id><name-alternatives><name xml:lang="en"><surname>Latkina</surname><given-names>Nonna V.</given-names></name><name xml:lang="ru"><surname>Латкина</surname><given-names>Нонна Вадимовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Surgeon, Department of Surgery</p></bio><bio xml:lang="ru"><p>канд. мед. наук, врач-хирург отделения хирургии</p></bio><email>latkina_enc@mail.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1876-2516</contrib-id><name-alternatives><name xml:lang="en"><surname>Akhmadullina</surname><given-names>Guzyal I.</given-names></name><name xml:lang="ru"><surname>Ахмадуллина</surname><given-names>Гузяль Илгисовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Associate Professor, Chair of Faculty Therapy with Courses of Endocrinology and Hematology, Endocrinologist</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доцент кафедры факультетской терапии с курсами эндокринологии и гематологии, врач-эндокринолог</p></bio><email>guzal-work@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Izhevsk State Medical Academy</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Ижевская государственная медицинская академия» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">The First Republican Clinical Hospital of Udmurt Republic</institution></aff><aff><institution xml:lang="ru">БУЗ УР «Первая республиканская клиническая больница Минздрава Удмуртской Республики»</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Endocrinology Research Centre</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр эндокринологии» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2023-06-03" publication-format="electronic"><day>03</day><month>06</month><year>2023</year></pub-date><pub-date date-type="pub" iso-8601-date="2023-06-22" publication-format="electronic"><day>22</day><month>06</month><year>2023</year></pub-date><volume>51</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>126</fpage><lpage>133</lpage><history><date date-type="received" iso-8601-date="2023-02-16"><day>16</day><month>02</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-05-12"><day>12</day><month>05</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Nurullina G.M., Pushkarev I.N., Pigarova E.A., Latkina N.V., Akhmadullina G.I.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Нуруллина Г.М., Пушкарев И.Н., Пигарова Е.А., Латкина Н.В., Ахмадуллина Г.И.</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Nurullina G.M., Pushkarev I.N., Pigarova E.A., Latkina N.V., Akhmadullina G.I.</copyright-holder><copyright-holder xml:lang="ru">Нуруллина Г.М., Пушкарев И.Н., Пигарова Е.А., Латкина Н.В., Ахмадуллина Г.И.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://almclinmed.ru/jour/article/view/5551">https://almclinmed.ru/jour/article/view/5551</self-uri><abstract xml:lang="en"><p>Pituitary apoplexy is a rare acute condition that can be caused by hemorrhage into the pituitary adenoma or its infarction. This is accompanied by severe headache, nausea, vomiting, photophobia, visual and oculomotor disorders, loss of consciousness, and can also lead to a decrease in the production of a number of hormones by the pituitary gland, i.e. hypopituitarism. We present a clinical case of a 42-year female patient with previously undiagnosed acromegaly and papillary thyroid cancer. The reason for the examination was clinical symptoms of pituitary apoplexy. Right hemithyroidectomy with central and lateral lymphadenectomy was performed for her papillary thyroid cancer, followed by radioactive iodine therapy due to an increased risk of cancer progression. Hemorrhage into the pituitary adenoma in this patient has led to panhypopituitarism and remission of acromegaly. Insulin-like growth factor 1 and growth hormone levels during oral glucose tolerance test were within the reference values, which made the diagnosis of acromegaly challenging.</p></abstract><trans-abstract xml:lang="ru"><p>Апоплексия гипофиза – редкое острое состояние, которое может быть вызвано кровоизлиянием в аденому гипофиза или возникать вследствие ее ишемии. Клиническая симптоматика сопровождается выраженной головной болью, тошнотой, рвотой, светобоязнью, зрительными и глазодвигательными нарушениями, потерей сознания, а также может приводить к снижению выработки гипофизом ряда гормонов – гипопитуитаризму. Мы приводим клиническое наблюдение пациентки 42 лет с ранее не диагностированными акромегалией и папиллярным раком щитовидной железы. Поводом для обследования стали клинические проявления апоплексии гипофиза. По поводу папиллярного рака щитовидной железы была проведена гемитиреоидэктомия справа с центральной и боковой лимфаденэктомией с последующей терапией радиоактивным йодом в связи с повышенным риском прогрессирования рака. Кровоизлияние в аденому гипофиза у данной пациентки привело к пангипопитуитаризму и ремиссии акромегалии, и показатели инсулиноподобного фактора роста 1 и соматотропного гормона в ходе орального глюкозотолерантного теста оказались в пределах нормальных значений, что усложнило постановку диагноза акромегалии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>acromegaly</kwd><kwd>pituitary adenoma</kwd><kwd>hypopituitarism</kwd><kwd>pituitary apoplexy</kwd><kwd>papillary thyroid cancer</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>акромегалия</kwd><kwd>аденома гипофиза</kwd><kwd>пангипопитуитаризм</kwd><kwd>апоплексия гипофиза</kwd><kwd>папиллярный рак щитовидной железы</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Fleseriu M, Biller BMK, Freda PU, Gadelha MR, Giustina A, Katznelson L, Molitch ME, Samson SL, Strasburger CJ, van der Lely AJ, Melmed S. 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