Almanac of Clinical MedicineAlmanac of Clinical MedicineАльманах клинической медицины2072-05052587-9294Moscow Regional Research and Clinical Institute (MONIKI)44510.18786/2072-0505-2016-44-5-568-579REVIEW ARTICLEОБЗОРNEOPLASMS IN ACROMEGALYНОВООБРАЗОВАНИЯ ПРИ АКРОМЕГАЛИИChikhI. D.ЧихИ. Д.
Russian Federation

MD, Chief of Department of Therapeutic Endocrinology

заведующая отделением терапевтической эндокринологии

trigolosova_ira@mail.ruTrigolosovaI. V.ТриголосоваИ. В.
Russian Federation

MD, PhD, Senior Research Fellow, Department of Therapeutic Endocrinology

канд. мед. наук, ст. науч. сотр. отделения терапевтической эндокринологии

trigolosova_ira@mail.ruDreval'A. V.ДревальА. В.
Russian Federation

MD, PhD, Professor, Head of Department of Therapeutic Endocrinology; Chief of Chair of Endocrinology, Postgraduate Training Faculty

д-р мед. наук, профессор, руководитель отделения терапевтической эндокринологии, заведующий кафедрой эндокринологии факультета усовершенствования врачей

trigolosova_ira@mail.ruTrigolosovA. V.ТриголосовА. В.
Russian Federation

MD, PhD, Senior Research Fellow, Department of Radiosurgery

канд. мед. наук, ст. науч. сотр. отделения радиохирургии

trigolosova_ira@mail.ruMoscow Regional Research and Clinical Institute (MONIKI)ГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»61/2 Shchepkina ul., Moscow, 129110, Russian Federation129110, г. Москва, ул. Щепкина, 61/2, Российская ФедерацияN.N. Blokhin Russian Cancer Research CenterФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Минздрава России24 Kashirskoe shosse, Moscow, 115478, Russian Federation115478, г. Москва, Каширское шоссе, 24, Российская Федерация150820164455685790301201703012017Copyright ©; 2016, Chikh I.D., Trigolosova I.V., Dreval' A.V., Trigolosov A.V.Copyright ©; 2016, Чих И.Д., Триголосова И.В., Древаль А.В., Триголосов А.В.2016Chikh I.D., Trigolosova I.V., Dreval' A.V., Trigolosov A.V.Чих И.Д., Триголосова И.В., Древаль А.В., Триголосов А.В.https://creativecommons.org/licenses/by/4.0https://almclinmed.ru/jour/article/view/445

Acromegaly is a  rare disease with increased growth hormone secretion most often caused by pituitary adenoma. Not adequately treated acromegaly may lead to early death related to increased rates of acute cardiovascular events, sleep apnea, metabolic disorders and malignancies. Prevalence of malignancies in acromegaly is in the range of 4.5 to 25%, with some specifics in their pathogenesis, and their proportion as mortality cause is 9 to 50%. Overall and cancer-related mortality in acromegaly are associated with activity of the disease. There is a direct correlation between high levels of insulin-like growth factor 1 and the risk of malignancies. The most common types of cancer in patients with acromegaly are colorectal (1 to 20%) and thyroid cancer (7.8 to 11%). This review of literature describes the results of epidemiological studies on malignancies and some aspects of their pathogenesis in patients with acromegaly.

Акромегалия – редкое заболевание, характеризующееся повышенной секрецией соматотропного гормона, что наиболее часто обусловлено наличием аденомы гипофиза. Отсутствие своевременного лечения акромегалии ведет к  преждевременной смерти больных, связанной с  повышением частоты развития острых сердечно-сосудистых осложнений, апноэ сна, метаболических нарушений и злокачественных новообразований. Частота злокачественных новообразований при акромегалии составляет от  4,5 до  25% (при этом механизмы их развития имеют ряд отличительных особенностей),  в  9–50%  случаев они становятся причиной гибели пациентов. При акромегалии общая смертность и смертность от онкологических заболеваний коррелирует с активностью заболевания. Установлена прямая зависимость между высоким уровнем инсулиноподобного ростового фактора 1 крови и риском развития злокачественных опухолей. У больных акромегалией наиболее часто встречаются злокачественные новообразования толстого кишечника (1–20%) и  щитовидной железы (7,8–11%). В  обзоре литературы отражены результаты эпидемиологических исследований злокачественных новообразований, а также некоторые аспекты их патогенеза у больных акромегалией.

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