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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Almanac of Clinical Medicine</journal-id><journal-title-group><journal-title xml:lang="en">Almanac of Clinical Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Альманах клинической медицины</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2072-0505</issn><issn publication-format="electronic">2587-9294</issn><publisher><publisher-name xml:lang="en">Moscow Regional Research and Clinical Institute (MONIKI)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">330</article-id><article-id pub-id-type="doi">10.18786/2072-0505-2016-44-2-140-147</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ARTICLES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">ERRORS IN FITTING RADIAL DOSE FUNCTION OF COBALT SOURCES FOR BRACHYTHERAPY WITH 3-5 DEGREE POLYNOMIALS</article-title><trans-title-group xml:lang="ru"><trans-title>ОШИБКИ АППРОКСИМАЦИИ РАДИАЛЬНОЙ ДОЗОВОЙ ФУНКЦИИ КОБАЛЬТОВЫХ ИСТОЧНИКОВ ДЛЯ БРАХИТЕРАПИИ ПОЛИНОМАМИ 3–5-Й СТЕПЕНИ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Belousov</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Белоусов</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD (in Physics and Mathematics), Associate Professor, Chair of Physics of Accelerators and Radiation Medicine, Faculty of Physics</p></bio><bio xml:lang="ru"><p>канд. физ.-мат. наук, доцент кафедры физики ускорителей и радиационной медицины физического факультета</p></bio><email>belousovav@physics.msu.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Belyanov</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Белянов</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Junior Research Fellow, Chair of Physics of Accelerators and Radiation Medi- cine, Faculty of Physics</p></bio><bio xml:lang="ru"><p>мл. науч. сотр. кафедры физики ускорителей и радиационной медицины физического факультета</p></bio><email>belousovav@physics.msu.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Chernyaev</surname><given-names>A. P.</given-names></name><name xml:lang="ru"><surname>Черняев</surname><given-names>А. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD (in Physics and Mathematics), Professor, Head of the Chair of Physics of Accelerators and Radiation Medicine, Faculty of Physics, Head of the Laboratory of Beam Technolo- gies and Medical Physics</p></bio><bio xml:lang="ru"><p>д-р физ.-мат. наук, профессор, заведующий кафедрой физики ускорителей и радиационной медицины физического факультета, заведующий лабораторией пучковых технологий и медицинской физики</p><p> </p></bio><email>belousovav@physics.msu.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff3"/><xref ref-type="aff" rid="aff4"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Lomonosov Moscow State University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Московский государственный университет имени М.В. Ломоносова»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">1 Leninskie  gory, Moscow, 119991, Russian Federation</institution></aff><aff><institution xml:lang="ru">119991, г. Москва, Ленинские  горы, 1, Российская Федерация</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">1 Leninskie  gory, Moscow, 119991, Russian Federation &#13;
Skobeltsyn Institute of Nuclear Physics, Lomonosov  Moscow State University</institution></aff><aff><institution xml:lang="ru">119991, г. Москва, Ленинские  горы, 1, Российская Федерация &#13;
Научно-исследовательский институт ядерной физики имени Д.В. Скобельцына Московского государственного университета им. М.В. Ломоносова</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">1 Leninskie gory, Moscow,  119991, Russian Federation</institution></aff><aff><institution xml:lang="ru">119991, г. Москва, Ленинские горы, 1/2, Российская Федерация</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2016-03-15" publication-format="electronic"><day>15</day><month>03</month><year>2016</year></pub-date><volume>44</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>140</fpage><lpage>147</lpage><history><date date-type="received" iso-8601-date="2016-06-26"><day>26</day><month>06</month><year>2016</year></date><date date-type="accepted" iso-8601-date="2016-06-26"><day>26</day><month>06</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2016, Belousov A.V., Belyanov A.A., Chernyaev A.P.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2016, Белоусов А.В., Белянов А.А., Черняев А.П.</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="en">Belousov A.V., Belyanov A.A., Chernyaev A.P.</copyright-holder><copyright-holder xml:lang="ru">Белоусов А.В., Белянов А.А., Черняев А.П.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://almclinmed.ru/jour/article/view/330">https://almclinmed.ru/jour/article/view/330</self-uri><abstract xml:lang="en"><p>Background: Providing quality insurance for radiation therapy implies high level of precision for determining absorbed dose, and therefore high level of precision for fitting radial dose function. 3-5  degree polynomials provide required precision, however, uncertainty of their coefficients may cause substantial errors. Aim: To investigate dependence of errors of calculating radial dose function with consideration of uncertainty of coefficients from different degrees of fitting polynomial. Materials and methods: Calculations were performed with software package GEANT4.9.6. Geometry and materials of the source correspond to the model BEBIGCo0.A86. Spectral structure of the source corresponds to the NuDat 2.6 database. Statistical processing was done using nonlinear least-square method. Results: Values of the radial dose function of Cobalt source for brachytherapy were calculated for given geometry. Conducted comparison of precisions of 3 to 5 degree polynomial approximations and possible uncertainties of results of radial dose function calculations. Conclusion: Withrequired precision of 25% and higher at the radius of 10 cm the optimal choice for radial dose approximation is the 3rd degree polynomial. </p></abstract><trans-abstract xml:lang="ru"><p>Актуальность. Качество лучевой терапии может быть гарантировано только при высокой точности определения поглощенной дозы, а  следовательно, высокой точности аппроксимации радиальной дозовой функции. Полиномы 3–5-й  степени обеспечивают требуемую точность, однако неопределенность их коэффициентов может приводить к  существенным погрешностям. Цель  – исследование погрешности вычисления радиальной дозовой функции кобальтового источника с  учетом неопределенности коэффициентов в зависимости от степени аппроксимационного полинома. Материал и  методы. Вычисления выполнены с  помощью программного комплекса GEANT4.9.6. Геометрия и  материалы источника соответствуют модели BEBIGCo0.A86. Спектральный состав источника соответствует данным NuDat 2.6. Статистическая обработка проведена нелинейным методом наименьших квадратов. Результаты. Вычислены значения радиальной дозовой функции кобальтового источника для брахитерапии в  заданной геометрии. Проведено сравнение точностей полиномиальных аппроксимаций степеней  3–5, а  также возможных неопределенностей результатов вычислений радиальной дозовой функции. Заключение. Для достижения неопределенности аппроксимирующей радиальной дозовой функции в 25% и менее на радиусе 10 см оптимальным выбором при аппроксимации радиальной дозовой функции представляются полиномы 3-й степени. </p></trans-abstract><kwd-group xml:lang="en"><kwd>approximation</kwd><kwd>brachytherapy</kwd><kwd>cobalt</kwd><kwd>radial dose function</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>аппроксимация</kwd><kwd>брахитерапия</kwd><kwd>кобальт</kwd><kwd>радиальная дозовая функция</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1.Nath R, Anderson LL, Luxton G, Weaver KA, Williamson JF, Meigooni AS. Dosimetry of interstitial brachytherapy sources: recommendations of the AAPM Radiation Therapy Committee Task Group No. 43. 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