Almanac of Clinical MedicineAlmanac of Clinical MedicineАльманах клинической медицины2072-05052587-9294Moscow Regional Research and Clinical Institute (MONIKI)28410.18786/2072-0505-2014-30-18-24ACTUAL PROBLEMS OF NEPHROLOGYАКТУАЛЬНЫЕ ВОПРОСЫ НЕФРОЛОГИИCLINICAL SIGNIFICANCE OF SERUM AND URINARY HEAT SHOCK PROTEIN 70 LEVEL ASSESSMENT IN PATIENTS WITH CHRONIC GLOMERULONEPHRITISКЛИНИЧЕСКОЕ ЗНАЧЕНИЕ ОПРЕДЕЛЕНИЯ СЫВОРОТОЧНОГО И МОЧЕВОГО ПОКАЗАТЕЛЕЙ БЕЛКА ТЕПЛОВОГО ШОКА-70 У БОЛЬНЫХ ХРОНИЧЕСКИМ ГЛОМЕРУЛОНЕФРИТОМChebotaryovaN. V.ЧеботареваН. В.
Russian Federation
BobkovaI. N.БобковаИ. Н.
Russian Federation
NeprintsevaN. I.НепринцеваН. И.
Russian Federation
KozlovskayaL. V.КозловскаяЛ. В.
Russian Federation
I.M. Sechenov First Moscow State Medical UniversityГБОУ ВПО Первый Московский государственный медицинский университет им. И.М. Сеченова150120143018240103201601032016Copyright ©; 2014, Chebotaryova N.V., Bobkova I.N., Neprintseva N.I., Kozlovskaya L.V.Copyright ©; 2014, Чеботарева Н.В., Бобкова И.Н., Непринцева Н.И., Козловская Л.В.2014Chebotaryova N.V., Bobkova I.N., Neprintseva N.I., Kozlovskaya L.V.Чеботарева Н.В., Бобкова И.Н., Непринцева Н.И., Козловская Л.В.https://creativecommons.org/licenses/by/4.0https://almclinmed.ru/jour/article/view/284

The levels of urinary heat shock protein-70 and serum antibodies to the heat shock protein-70 were assessed in 79 patients with different course variants of the chronic glomerulonephritis. The indices studied were higher in patients with an active course of the disease (expressed urinary and nephritic syndromes, especially if associated with transient renal disturbances which reflected the degree of lesion and activation of the renal self-defence system. Decrease of the serum level of antibodies to the heat shock protein-70 was an unfavorable factor of the nephrotic syndrome persistence despite the immunosuppressive therapy.

Уровни белка теплового шока-70 в моче и антител к белку теплового шока-70 в сыворотке крови были оценены у 79 больных с различными вариантами течения хронического гломерулонефрита. Изученные показатели были выше у больных с активным течением этого заболевания - выраженным мочевым и нефротическим синдромами, особенно при сочетании с преходящим нарушением функции почек, что отражает степень повреждения и активации механизмов самозащиты почки. Снижение уровня антител к белку теплового шока-70 в сыворотке крови являлось неблагоприятным прогностическим фактором персистирования нефротического синдрома, несмотря на проводимую иммуносупрессивную терапию.

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