Almanac of Clinical MedicineAlmanac of Clinical Medicine2072-05052587-9294Moscow Regional Research and Clinical Institute (MONIKI)22910.18786/2072-0505-2015-36-71-73ДИРОФИЛЯРИОЗ ПРИДАТОЧНОГО АППАРАТА ГЛАЗА И ОРБИТЫGrishinaE. E.<p>MD, PhD, Professor, Leading Research Associate, Ophthalmology Department</p>eyelena@mail.ruRyabtsevaA. A.<p>MD, PhD, Professor, the Head of the Ophthalmology Department</p>fake@neicon.ruBelovaT. V.<p>Physician, Ophthalmology Department</p>fake@neicon.ruMoscow Regional Research and Clinical Institute (MONIKI)150120153671732102201621022016Copyright © 2015, Grishina E.E., Ryabtseva A.A., Belova T.V.2015<p><strong>Background: </strong>Floppy eyelid syndrome is a rare disorder characterized by tarsal atonia, common spontaneous eversion of the upper eyelids in conjunction with chronic papillary conjunctivitis. Floppy eyelid syndrome is a frequent cause of recurrent keratitis of different severity up to corneal ulceration. </p><p><strong>Aim: </strong>To assess tear production, tear film and status of cornea in patients with floppy eyelid syndrome. <strong>Materials and methods: </strong>We examined 8 women aged 47–81 years (median 59 years) with clinical signs of floppy eyelid syndrome. For functional assessment, Schirmer and Norn tests were used. </p><p><strong>Results: </strong>All patients had dry eye syndrome due to increased evaporation and fluid loss from the ocular surface in combination with meibomian gland dysfunction. In all cases, keratitis of varied severity was diagnosed: pitted corneal erosions in 7 patients, severe keratitis on 1 patient. In this patient, untimely diagnosis of floppy eyelid syndrome and inadequate treatment resulted in the development of purulent corneal ulcer, endophthalmitis and subsequent eye enucleation. In all patients, medical treatment involved artificial tear, night gauze bandage and therapeutic eye gels. </p><p><strong>Conclusion: </strong>In patients with floppy eye syndrome, early diagnosis and timely treatment may prevent the development of corneal ulcer.</p>floppy eyelid syndromedry eye syndromepapillary conjunctivitismeibomian gland dysfunctionkeratitiscorneal ulcerсиндром «вялых век»синдром сухого глазапапиллярный конъюнктивитдисфункция мейбомиевых железкератитязва роговицы[1. Culbertson WW, Ostler HB. The floppy eyelid syndrome. Am J Ophthalmol. 1981;92(4):568–75.][2. McNab AA. Floppy eyelid syndrome and obstructive sleep apnea. Ophthal Plast Reconstr Surg. 1997;13(2):98–114.][3. Сомов ЕЕ, ред. Синдромы слезной дисфункции (анатомо-физиологические основы, диагностика, клиника и лечение). СПб.: Человек; 2011. 160 с.(Somov EE, editor. Tear dysfunction syndromes (anatomical and pathophysiological background, manifestations and treatment). Saint Petersburg: Chelovek; 2011. 160 p. Russian).][4. Pham TT, Perry JD. Floppy eyelid syndrome. Curr Opin Ophthalmol. 2007;18(5):430–3.][5. Netland PA, Sugrue SP, Albert DM, Shore JW. Histopathologic features of the floppy eyelid syndrome. Involvement of tarsal elastin. Ophthalmology. 1994;101(1):174–81.][6. Gonnering RS, Sonneland PR. Meibomian gland dysfunction in floppy eyelid syndrome. Ophthal Plast Reconstr Surg. 1987;3(2):99–103.][7. Liu DT, Di Pascuale MA, Sawai J, Gao YY, Tseng SC. Tear film dynamics in floppy eyelid syndrome. Invest Ophthalmol Vis Sci.][2005;46(4):1188–94.][8. Acar M, Firat H, Acar U, Ardic S. Ocular surface assessment in patients with obstructive sleep apnea-hypopnea syndrome. Sleep Breath. 2013;17(2):583–8.]