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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Almanac of Clinical Medicine</journal-id><journal-title-group><journal-title xml:lang="en">Almanac of Clinical Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Альманах клинической медицины</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2072-0505</issn><issn publication-format="electronic">2587-9294</issn><publisher><publisher-name xml:lang="en">Moscow Regional Research and Clinical Institute (MONIKI)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">185</article-id><article-id pub-id-type="doi">10.18786/2072-0505-2014-34-36-41</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>DERMATO-ONCOLOGY</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ДЕРМАТООНКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">ERUPTIVE KERATOACANTHOMA OF GRZYBOWSKI</article-title><trans-title-group xml:lang="ru"><trans-title>ЭРУПТИВНАЯ КЕРАТОАКАНТОМА ТИПА ГРЖЕБОВСКИ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Molochkov</surname><given-names>V. A.</given-names></name><name xml:lang="ru"><surname>Молочков</surname><given-names>В. А</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Professor, Head of the Dermatovenereology and Dermato-Oncology Department</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор, руководитель отделения дерматовенерологии и дерматоонкологии</p></bio><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kuntsevich</surname><given-names>Zh. S.</given-names></name><name xml:lang="ru"><surname>Кунцевич</surname><given-names>Ж. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Associate Professor, Dermatovenereology and Dermato-Oncology Department</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доцент кафедры дерматовенерологии и дерматоонкологии</p></bio><email>j_s_k@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bobrov</surname><given-names>M. A.</given-names></name><name xml:lang="ru"><surname>Бобров</surname><given-names>М. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Research Associate, Department of Pathological Anatomy</p></bio><bio xml:lang="ru"><p>науч. сотр. патологоанатомического отделения</p></bio><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dibirova</surname><given-names>S. A.</given-names></name><name xml:lang="ru"><surname>Дибирова</surname><given-names>С. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Fellow, Department of Skin and Venereal Diseases, Institute for Professional Education </p><p> </p></bio><bio xml:lang="ru"><p>аспирант кафедры кожных и венерических болезней Института профессионального образования</p></bio><xref ref-type="aff" rid="aff3"/><xref ref-type="aff" rid="aff4"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Moscow Regional Research and Clinical Institute (MONIKI)</institution></aff><aff><institution xml:lang="ru">ГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">61/2 Shchepkina ul., Moscow, 129110, Russian Federation</institution></aff><aff><institution xml:lang="ru">129110, г. Москва, ул. Щепкина, 61/2, Российская Федерация</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО «Первый Московский медицинский университет им. И.М. Сеченова» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">8/2 Trubetskaya ul., Moscow, 119991, Russian Federation</institution></aff><aff><institution xml:lang="ru">117997, г. Москва, ул. Трубецкая, 8/2, Российская Федерация</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2014-08-15" publication-format="electronic"><day>15</day><month>08</month><year>2014</year></pub-date><issue>34</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>36</fpage><lpage>41</lpage><history><date date-type="received" iso-8601-date="2016-02-18"><day>18</day><month>02</month><year>2016</year></date><date date-type="accepted" iso-8601-date="2016-02-18"><day>18</day><month>02</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2014, Molochkov V.A., Kuntsevich Z.S., Bobrov M.A., Dibirova S.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2014, Молочков В.А., Кунцевич Ж.С., Бобров М.А., Дибирова С.А.</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="en">Molochkov V.A., Kuntsevich Z.S., Bobrov M.A., Dibirova S.A.</copyright-holder><copyright-holder xml:lang="ru">Молочков В.А., Кунцевич Ж.С., Бобров М.А., Дибирова С.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://almclinmed.ru/jour/article/view/185">https://almclinmed.ru/jour/article/view/185</self-uri><abstract xml:lang="en"><p>The article presents a case of a very rare disorder – generalized eruptive keratoacanthoma of Grzybowski in a woman aged 82 years old. The disease is characterized by sudden emergence of hundreds or thousands of neoplasms (2–5 cm in diameters) rapidly spreading throughout the body skin. It is frequently associated with internistic cancer. In this case, generalized eruptive keratoacanthoma of Grzybowski was diagnosed 4 years after the disease onset. The authors emphasize the role of proper diagnosis and treatment of this pathology. Aromatic retinoids were highly effective in the therapy of generalized eruptive keratoacanthoma of Grzybowski.</p></abstract><trans-abstract xml:lang="ru"><p>В статье представлен случай лечения чрезвычайно редкой патологии  – множественной эруптивной кератоакантомы типа Гржебовски у  пациентки 82 лет. Заболевание характеризуется внезапным возникновением сотни или тысячи опухолевых элементов диаметром 2–5 см, в  течение короткого времени распространяющихся по всему кожному покрову. Часто заболевание ассоциируется с  раком внутренних органов. Использованные авторами подходы к диагностике и лечению не только позволили поставить диагноз множественной эруптивной кератоакантомы типа Гржебовски пациентке, в  течение 4 лет страдающей этим заболеванием, но и  продемонстрировали высокую эффективность примененной терапии. Показана эффективность ароматических ретиноидов в лечении множественной эруптивной кератоакантомы типа Гржебовски.</p></trans-abstract><kwd-group xml:lang="en"><kwd>keratoacanthoma</kwd><kwd>generalized eruptive keratoacanthoma of Grzybowski</kwd><kwd>aromatic retinoids</kwd><kwd>acitretin</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>кератоакантома</kwd><kwd>множественная эруптивная кератоакантома типа Гржебовски</kwd><kwd>ароматические ретиноиды</kwd><kwd>ацитретин</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1. Nofal A, Assaf M, Nofal E, Alradi M. 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