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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Almanac of Clinical Medicine</journal-id><journal-title-group><journal-title xml:lang="en">Almanac of Clinical Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Альманах клинической медицины</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2072-0505</issn><issn publication-format="electronic">2587-9294</issn><publisher><publisher-name xml:lang="en">Moscow Regional Research and Clinical Institute (MONIKI)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">17669</article-id><article-id pub-id-type="doi">10.18786/2072-0505-2026-54-010</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>POINT OF VIEW</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ТОЧКА ЗРЕНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Mythologization of statistics in biomedical research</article-title><trans-title-group xml:lang="ru"><trans-title>Мифологизация статистики в биомедицинских исследованиях</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6610-9824</contrib-id><name-alternatives><name xml:lang="en"><surname>Slavenko</surname><given-names>Matvei</given-names></name><name xml:lang="ru"><surname>Славенко</surname><given-names>Матвей Григорьевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MSc (in Probability and Statistics), Lecturer; Biostatistician</p></bio><bio xml:lang="ru"><p>преподаватель; биостатистик</p></bio><email>matvei.slavenko@gmail.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8952-8386</contrib-id><name-alternatives><name xml:lang="en"><surname>Mironenko</surname><given-names>Olga N.</given-names></name><name xml:lang="ru"><surname>Мироненко</surname><given-names>Ольга Николаевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD (in Economics), Lecturer</p></bio><bio xml:lang="ru"><p>канд. экон. наук, преподаватель</p></bio><email>freelomir@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4891-9169</contrib-id><name-alternatives><name xml:lang="en"><surname>Kuznetsov</surname><given-names>Maksim S.</given-names></name><name xml:lang="ru"><surname>Кузнецов</surname><given-names>Максим Сергеевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Lecturer; Senior Laboratory Technician, Department of Propaedeutics of Internal Diseases named after Professor S.S. Zimnitsky</p></bio><bio xml:lang="ru"><p>преподаватель; ст. лаборант кафедры пропедевтики внутренних болезней имени профессора С.С. Зимницкого</p></bio><email>bqmaks@gmail.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5694-4348</contrib-id><name-alternatives><name xml:lang="en"><surname>Bakin</surname><given-names>Evgeny A.</given-names></name><name xml:lang="ru"><surname>Бакин</surname><given-names>Евгений Александрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD (in Engineering), Lecturer</p></bio><bio xml:lang="ru"><p>канд. техн. наук, преподаватель</p></bio><email>eugene.bakin@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Bioinformatics Institute</institution></aff><aff><institution xml:lang="ru">ООО «Институт биоинформатики и биостатистики»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Motol and Homolka University Hospital</institution></aff><aff><institution xml:lang="ru">Университетская больница Мотол и Гомолка</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Kazan State Medical University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2026-08-28" publication-format="electronic"><day>28</day><month>08</month><year>2026</year></pub-date><volume>54</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>104</fpage><lpage>112</lpage><history><date date-type="received" iso-8601-date="2026-06-25"><day>25</day><month>06</month><year>2026</year></date><date date-type="accepted" iso-8601-date="2026-08-12"><day>12</day><month>08</month><year>2026</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2026, Slavenko M.G., Mironenko O.N., Kuznetsov M.S., Bakin E.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2026, Славенко М.Г., Мироненко О.Н., Кузнецов М.С., Бакин Е.А.</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="en">Slavenko M.G., Mironenko O.N., Kuznetsov M.S., Bakin E.A.</copyright-holder><copyright-holder xml:lang="ru">Славенко М.Г., Мироненко О.Н., Кузнецов М.С., Бакин Е.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://almclinmed.ru/jour/article/view/17669">https://almclinmed.ru/jour/article/view/17669</self-uri><abstract xml:lang="en"><p>Reproducibility of scientific research has become a major concern in recent years. Inappropriate application of statistical analysis methods by researchers is considered one of the causes of the reproducibility crisis. Drawing on the concept of "statistical myths" – persistent, recurring distortions of statistical concepts – it is argued that these myths are systematic rather than accidental, serve specific functions, and reflect a deep methodological gap between the research domain and the practice of statistical analysis. The relationship between scientific and statistical inference is shown in the form of a biomedical research framework consisting of seven stages: conceptualization and formulation of the research question; operationalization; selection of the estimand; statistical model building and application; interpretation of the estimate accounting for uncertainty; clinical interpretation; and answering the research question. The framework is illustrated using examples from three real-world studies across various medical fields. Based on their functions, the authors classify statistical myths into four categories: epistemological, fundamental, instrumental, and terminological. The defining characteristics and examples of each type are provided, alongside an analysis of several widespread myths. The proposed approach allows statistical myths to be viewed not merely as a pedagogical issue, but as indicators of deeper disruptions in research logic. From a methodological perspective, rather than memorizing yet another list of "correct" and "incorrect" statistical practices, researchers are encouraged to proceed systematically from the research question at hand to its statistical formalization.</p></abstract><trans-abstract xml:lang="ru"><p>В последние годы большое внимание уделяется проблеме воспроизводимости научных исследований. В качестве одной из причин кризиса воспроизводимости выделяют некорректное применение исследователями методов статистического анализа. С опорой на концепцию «статистических мифов» (устойчивое, воспроизводящееся искажение статистических понятий) утверждается, что мифы носят неслучайный характер, имеют свои функции и свидетельствуют о глубоком методологическом разрыве между предметной областью и практикой статистического анализа. Связь между научным и статистическим выводами показана в виде схемы биомедицинского исследования, состоящего из семи этапов: концептуализация и постановка исследовательского вопроса; операционализация; выбор эстиманда; создание и применение статистической модели; интерпретация оценки с учетом неопределенности; клиническая интерпретация; ответ на исследовательский вопрос. Схема иллюстрирована примерами трех реальных исследований из различных областей медицины. На основании выполняемых функций авторы классифицируют мифы на эпистемологические, фундаментальные, инструментальные и терминологические. Приведены характерные признаки и примеры каждого типа, проанализировано несколько популярных мифов. Предложенный подход позволяет рассматривать статистические мифы не только как педагогическую проблему, но и как индикатор более глубоких нарушений логики исследования. С методической точки зрения исследователю предлагается не запомнить очередной список «правильных» и «неправильных» статистических действий, а последовательно двигаться от научного вопроса к способу его статистической формализации.</p></trans-abstract><kwd-group xml:lang="en"><kwd>biostatistics</kwd><kwd>biomedical research</kwd><kwd>methodology</kwd><kwd>myth</kwd><kwd>reproducibility</kwd><kwd>statistical inference</kwd><kwd>scientific inference</kwd><kwd>terminology</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>биостатистика</kwd><kwd>биомедицинские исследования</kwd><kwd>методология</kwd><kwd>миф</kwd><kwd>воспроизводимость</kwd><kwd>статистический вывод</kwd><kwd>научный вывод</kwd><kwd>терминология</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Baker M. 1,500 scientists lift the lid on reproducibility. 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