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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Almanac of Clinical Medicine</journal-id><journal-title-group><journal-title xml:lang="en">Almanac of Clinical Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Альманах клинической медицины</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2072-0505</issn><issn publication-format="electronic">2587-9294</issn><publisher><publisher-name xml:lang="en">Moscow Regional Research and Clinical Institute (MONIKI)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1726</article-id><article-id pub-id-type="doi">10.18786/2072-0505-2022-50-043</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEW ARTICLE</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Сognitive rehabilitation methods in multiple sclerosis patients</article-title><trans-title-group xml:lang="ru"><trans-title>Методы когнитивной реабилитации у пациентов с рассеянным склерозом</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7042-1391</contrib-id><name-alternatives><name xml:lang="en"><surname>Moskvina</surname><given-names>Ekaterina Y.</given-names></name><name xml:lang="ru"><surname>Москвина</surname><given-names>Екатерина Юрьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Assistant Professor, Chair of Nervous Diseases, Neurosurgery and Medical Genetics</p></bio><bio xml:lang="ru"><p>ассистент кафедры нервных болезней, нейрохирургии и медицинской генетики</p></bio><email>moskwina.cat@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2478-727X</contrib-id><name-alternatives><name xml:lang="en"><surname>Volkova</surname><given-names>Larisa I.</given-names></name><name xml:lang="ru"><surname>Волкова</surname><given-names>Лариса Ивановна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Professor, Head of Chair of Nervous Diseases, Neurosurgery and Medical Genetics</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор, заведующая кафедрой нервных болезней, нейрохирургии и медицинской генетики</p></bio><email>vli@okb1.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4595-1024</contrib-id><name-alternatives><name xml:lang="en"><surname>Koryakina</surname><given-names>Oksana V.</given-names></name><name xml:lang="ru"><surname>Корякина</surname><given-names>Оксана Валерьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Associate Professor, Chair of Nervous Diseases, Neurosurgery and Medical Genetics</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доцент кафедры нервных болезней, нейрохирургии и медицинской генетики</p></bio><email>koryakina09@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Ural State Medical University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Уральский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2022-11-21" publication-format="electronic"><day>21</day><month>11</month><year>2022</year></pub-date><pub-date date-type="pub" iso-8601-date="2022-12-08" publication-format="electronic"><day>08</day><month>12</month><year>2022</year></pub-date><volume>50</volume><issue>5</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>321</fpage><lpage>328</lpage><history><date date-type="received" iso-8601-date="2022-09-07"><day>07</day><month>09</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-11-11"><day>11</day><month>11</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Moskvina E.Y., Volkova L.I., Koryakina O.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, Москвина Е.Ю., Волкова Л.И., Корякина О.В.</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Moskvina E.Y., Volkova L.I., Koryakina O.V.</copyright-holder><copyright-holder xml:lang="ru">Москвина Е.Ю., Волкова Л.И., Корякина О.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://almclinmed.ru/jour/article/view/1726">https://almclinmed.ru/jour/article/view/1726</self-uri><abstract xml:lang="en"><p>The prevalence of cognitive impairment in patients with multiple sclerosis is 40 to 65%. Improvement of cognitive-oriented therapy and search for its new techniques is considered to be promising for slowing the progression or for recovery of cognitive functions. It is related to low efficacy of medical treatment, preserved neuroplasticity in most patients with multiple sclerosis, positive results of studies on selected cognitive rehabilitation techniques in other nervous system disorders. The spectrum of techniques for cognitive training varies from technically feasible methods using a sheet of paper and a pen to the most advanced ones, such as the use of immersive virtual reality. The effectiveness of cognitive rehabilitation in patients with multiple sclerosis with virtual reality technologies has not been studied in large-scale randomized placebo-controlled studies.</p></abstract><trans-abstract xml:lang="ru"><p>Частота встречаемости когнитивных нарушений у пациентов с рассеянным склерозом составляет от 40 до 65%. Усовершенствование и поиск новых способов когнитивно-ориентированной терапии считается перспективным направлением в отношении замедления прогрессирования или восстановления когнитивных функций. Это обусловлено низкой эффективностью медикаментозной терапии, сохранением нейропластичности у большинства больных рассеянным склерозом, положительными результатами исследований отдельных методик когнитивной реабилитации при других заболеваниях нервной системы. Спектр методик для проведения когнитивного тренинга варьирует от технически простых с использованием листа бумаги и ручки до наиболее передовых, таких как применение иммерсивной виртуальной реальности. При этом эффективность когнитивной реабилитации при рассеянном склерозе с помощью технологий виртуальной реальности не изучалась в рамках крупномасштабных рандомизированных плацебоконтролируемых исследований.</p></trans-abstract><kwd-group xml:lang="en"><kwd>multiple sclerosis</kwd><kwd>cognitive rehabilitation</kwd><kwd>immersive virtual reality</kwd><kwd>cognitive impairment</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рассеянный склероз</kwd><kwd>когнитивная реабилитация</kwd><kwd>иммерсивная виртуальная реальность</kwd><kwd>когнитивные нарушения</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Gusev EI, Boyko AN, Stolyarov ID. [Multiple Sclerosis]. Moscow: Real Time; 2009. 296 p.</mixed-citation><mixed-citation xml:lang="ru">Гусев ЕИ, Бойко АН, Столяров ИД. Рассеянный склероз. 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