Almanac of Clinical MedicineAlmanac of Clinical MedicineАльманах клинической медицины2072-05052587-9294Moscow Regional Research and Clinical Institute (MONIKI)171110.18786/2072-0505-2022-50-028REVIEW ARTICLEОБЗОРReview ArticleModifiable nutritional factors in hyperuricemia and goutМодифицируемые факторы питания при гиперурикемии и подагреhttps://orcid.org/0000-0002-7542-818912779903300GeorginovaOlga A.ГеоргиноваОльга Анатольевна
Russian Federation

MD, PhD, Assistant Professor, Chair of Internal Medicine, Faculty of Fundamental Medicine, General Physician, Rheumatologist, Department of Internal Medicine

канд. мед. наук, ассистент кафедры внутренних болезней факультета фундаментальной медицины, врач-терапевт, врач-ревматолог отдела внутренних болезней

olga.georginova@gmail.comhttps://orcid.org/0000-0002-4010-0386AstashkevichPolina N.АсташкевичПолина Николаевна
Russian Federation

5th year Student, Faculty of Fundamental Medicine

студентка 5-го курса факультета фундаментальной медицины

mrspolly11@gmail.comhttps://orcid.org/0000-0001-6175-1076KrasnovaTatyana N.КрасноваТатьяна Николаевна
Russian Federation

MD, PhD, Associate Professor, Head of Chair of Internal Medicine, Faculty of Fundamental Medicine, Leading Research Fellow, Department of Internal Medicine

канд. мед. наук, доцент, заведующая кафедрой внутренних болезней факультета фундаментальной медицины, вед. науч. сотр. отдела внутренних болезней

krasnovamgu@yandex.ruM.V. Lomonosov Moscow State UniversityФГБОУ ВО «Московский государственный университет имени М.В. Ломоносова»16092022291120225042642732107202208092022Copyright ©; 2022, Georginova O.A., Astashkevich P.N., Krasnova T.N.Copyright ©; 2022, Георгинова О.А., Асташкевич П.Н., Краснова Т.Н.2022Georginova O.A., Astashkevich P.N., Krasnova T.N.Георгинова О.А., Асташкевич П.Н., Краснова Т.Н.https://creativecommons.org/licenses/by-nc/4.0https://almclinmed.ru/jour/article/view/1711

Uric acid is an independent risk factor for socially important diseases, such as chronic heart failure and chronic kidney disease. The review summarizes current data on the impact of nutrition as a presumably modifiable factor into the development of hyperuricemia and gout. The authors describe biochemical mechanisms underlying hyperuricemia and present data on the influence of excessive intake of fructose, purines, and various alcohol-containing drinks on the risk of gout. Favorable impact of vitamin C supplements, coffee, cherry juice, some chemical elements (magnesium, zinc, and copper) on uric acid levels has been shown, as well as the impact of intake of low fat dairy products, polyphenols, food fibers, and omega-3 polyunsaturated fatty acids on the incidence of hyperuricemia. The information presented in the review can be used in clinical practice for preparation of an individualized nutritional plan aimed at normalization of uric acid levels. This would minimize the use of agents affecting the synthesis of uric acid and slow down the progression of chronic heart failure and chronic kidney disease.

Мочевая кислота – независимый фактор риска социально значимых болезней, таких как хроническая сердечная недостаточность и хроническая болезнь почек. В обзоре обобщены современные данные о вкладе питания как предположительного модифицируемого фактора в развитие гиперурикемии и подагры. Описаны биохимические механизмы, лежащие в основе гиперурикемии. Представлены данные о влиянии избыточного потребления фруктозы, пуринов, различных типов алкогольных напитков на риск возникновения подагры. Продемонстрировано положительное влияние добавок витамина C, кофе, вишневого сока, отдельных химических элементов (магний, цинк, медь) на концентрацию мочевой кислоты. Показан вклад употребления молочных продуктов c низким содержанием жира, полифенолов, пищевых волокон, омега-3-полиненасыщенных жирных кислот в частоту развития гиперурикемии. Приведенные в обзоре сведения могут быть использованы в клинической практике при составлении индивидуального рациона питания с целью нормализации уровня мочевой кислоты, что позволит минимизировать назначение препаратов, влияющих на синтез мочевой кислоты, и замедлить прогрессирование хронической сердечной недостаточности и хронической болезни почек.

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