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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Almanac of Clinical Medicine</journal-id><journal-title-group><journal-title xml:lang="en">Almanac of Clinical Medicine</journal-title><trans-title-group xml:lang="ru"><trans-title>Альманах клинической медицины</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2072-0505</issn><issn publication-format="electronic">2587-9294</issn><publisher><publisher-name xml:lang="en">Moscow Regional Research and Clinical Institute (MONIKI)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">16246</article-id><article-id pub-id-type="doi">10.18786/2072-0505-2023-51-043</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">The clinical case of a combination of ankylosing spondylitis, ulcerative colitis and rheumatoid arthritis in one patient: where is the intersection point?</article-title><trans-title-group xml:lang="ru"><trans-title>Сочетание анкилозирующего спондилита, язвенного колита и ревматоидного артрита у одного пациента: где точка пересечения?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7542-8189</contrib-id><name-alternatives><name xml:lang="en"><surname>Georginova</surname><given-names>Olga A.</given-names></name><name xml:lang="ru"><surname>Георгинова</surname><given-names>Ольга Анатольевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Rheumatologist, Associate Professor, Chair of Internal Diseases, Faculty of Fundamental Medicine</p></bio><bio xml:lang="ru"><p>канд. мед. наук, врач-ревматолог, доцент кафедры внутренних болезней факультета фундаментальной медицины</p></bio><email>olga.georginova@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2387-9930</contrib-id><name-alternatives><name xml:lang="en"><surname>Makarov</surname><given-names>Egor A.</given-names></name><name xml:lang="ru"><surname>Макаров</surname><given-names>Егор Алексеевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Assistant Professor, Chair of Internal Diseases, Faculty of Fundamental Medicine</p></bio><bio xml:lang="ru"><p>канд. мед. наук, ассистент кафедры внутренних болезней факультета фундаментальной медицины</p></bio><email>embrevas1507@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7362-176X</contrib-id><name-alternatives><name xml:lang="en"><surname>Budko</surname><given-names>Anton A.</given-names></name><name xml:lang="ru"><surname>Будко</surname><given-names>Антон Александрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Resident Physician, Chair of Internal Diseases, Faculty of Fundamental Medicine</p></bio><bio xml:lang="ru"><p>ординатор кафедры внутренних болезней факультета фундаментальной медицины</p></bio><email>anton-budko@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7901-6635</contrib-id><name-alternatives><name xml:lang="en"><surname>Avdeev</surname><given-names>Vladimir G.</given-names></name><name xml:lang="ru"><surname>Авдеев</surname><given-names>Владимир Георгиевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Associate Professor, Chair of Internal Diseases, Faculty of Fundamental Medicine; Gastroenterologist, Medical Research and Educational Center</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доцент кафедры внутренних болезней факультета фундаментальной медицины, врач-гастроэнтеролог Медицинского научно-образовательного центра</p></bio><email>avdeevvg@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8122-1275</contrib-id><name-alternatives><name xml:lang="en"><surname>Gorbunov</surname><given-names>Roman M.</given-names></name><name xml:lang="ru"><surname>Горбунов</surname><given-names>Роман Михайлович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Ultrasound Physician, Medical Research and Educational Center</p></bio><bio xml:lang="ru"><p>врач ультразвуковой диагностики Медицинского научно-образовательного центра</p></bio><email>gorbunov.roman82@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7533-9867</contrib-id><name-alternatives><name xml:lang="en"><surname>Plotnikova</surname><given-names>Maria L.</given-names></name><name xml:lang="ru"><surname>Плотникова</surname><given-names>Мария Леонидовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Roentgenologist, Medical Research and Educational Center</p></bio><bio xml:lang="ru"><p>врач-рентгенолог Медицинского научно-образовательного центра</p></bio><email>mashamotyleva@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6175-1076</contrib-id><name-alternatives><name xml:lang="en"><surname>Krasnova</surname><given-names>Tatiana N.</given-names></name><name xml:lang="ru"><surname>Краснова</surname><given-names>Татьяна Николаевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Head of Chair of Internal Diseases, Faculty of Fundamental Medicine</p></bio><bio xml:lang="ru"><p>канд. мед. наук, заведующая кафедрой внутренних болезней факультета фундаментальной медицины</p></bio><email>krasnovamgu@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Lomonosov Moscow State University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Московский государственный университет имени М.В. Ломоносова»</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2023-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2023</year></pub-date><pub-date date-type="pub" iso-8601-date="2023-12-10" publication-format="electronic"><day>10</day><month>12</month><year>2023</year></pub-date><volume>51</volume><issue>7</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>407</fpage><lpage>416</lpage><history><date date-type="received" iso-8601-date="2023-09-25"><day>25</day><month>09</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-12-12"><day>12</day><month>12</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Georginova O.A., Makarov E.A., Budko A.A., Avdeev V.G., Gorbunov R.M., Plotnikova M.L., Krasnova T.N.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Георгинова О.А., Макаров Е.А., Будко А.А., Авдеев В.Г., Горбунов Р.М., Плотникова М.Л., Краснова Т.Н.</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Georginova O.A., Makarov E.A., Budko A.A., Avdeev V.G., Gorbunov R.M., Plotnikova M.L., Krasnova T.N.</copyright-holder><copyright-holder xml:lang="ru">Георгинова О.А., Макаров Е.А., Будко А.А., Авдеев В.Г., Горбунов Р.М., Плотникова М.Л., Краснова Т.Н.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://almclinmed.ru/jour/article/view/16246">https://almclinmed.ru/jour/article/view/16246</self-uri><abstract xml:lang="en"><p>We describe a clinical observation of a 64-year old Caucasian patient with a longstanding ankylosing spondylitis, who was admitted to the clinic for diarrhea and joint syndrome. Physical and X-ray examination showed that his musculoskeletal system disorder was represented by ankylosing spondylitis, symmetrical erosive polyarthritis of the metacarpophalangeal joints, and wrist joint ankylosis. Laboratory work-up identified that the patient was HLA-B27 positive, had high rheumatoid factor and anti-citrulline antibodies levels. At colonoscopy, there were signs of ulcerative colitis. After the differential diagnosis procedures, we were able to conclude that the patient had a combination of rheumatoid arthritis, ankylosing spondylitis, and ulcerative colitis as three independent but associated disorders. The first description of these three autoimmune diseases in one patient can be of interest for clinicians.</p></abstract><trans-abstract xml:lang="ru"><p>Пациент 64 лет европеоидной расы, длительное время страдающий анкилозирующим спондилоартритом, поступил в клинику в связи с диареей и суставным синдромом. При обследовании установлено, что поражение опорно-двигательного аппарата представлено анкилозирующим спондилитом, симметричным эрозивным полиартритом пястно-фаланговых суставов, анкилозом суставов запястья, выявленными при осмотре и рентгенологически подтвержденными. Лабораторные тесты показали положительный HLA-B27, высокий уровень ревматоидного фактора и антицитруллиновых антител. По данным колоноскопии – признаки язвенного колита. После проведения дифференциальной диагностики у пациента выявлено сочетание ревматоидного артрита, анкилозирующего спондилита и язвенного колита как трех независимых, но ассоциированных заболеваний. Описания этих трех аутоиммунных заболеваний у одного и того же пациента ранее зарегистрировано не было, что может представлять интерес для клинициста.</p></trans-abstract><kwd-group xml:lang="en"><kwd>ankylosing spondylitis</kwd><kwd>ulcerative colitis</kwd><kwd>rheumatoid arthritis</kwd><kwd>HLA-B27</kwd><kwd>rheumatoid factor</kwd><kwd>anti-citrulline antibodies</kwd><kwd>clinical case</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>анкилозирующий спондилит</kwd><kwd>язвенный колит</kwd><kwd>ревматоидный артрит</kwd><kwd>HLA-B27</kwd><kwd>ревматоидный фактор</kwd><kwd>антицитруллинированные антитела</kwd><kwd>клинический случай</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Xu H, Yin J. HLA risk alleles and gut microbiome in ankylosing spondylitis and rheumatoid arthritis. 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