Almanac of Clinical MedicineAlmanac of Clinical Medicine2072-05052587-9294Moscow Regional Research and Clinical Institute (MONIKI)157510.18786/2072-0505-2022-50-015Review ArticleAcute arthritis associated with COVID-19TaradinGennadiy G.<p>MD, PhD, Associate Professor, Head of Chair of Therapy, Faculty of Internship and Postgraduate Training named after A.I. Dyadyk; Senior Research Fellow, Department of Urgent Cardiology and Cardiac Surgery</p>taradin@inbox.ruhttps://orcid.org/0000-0003-3984-8482KuglerTatyana E.<p>MD, PhD, Associate Professor, Chair of Therapy, Faculty of Internship and Postgraduate Training named after A.I. Dyadyk</p>kugler2@mail.ruhttps://orcid.org/0000-0001-5547-6741MalovichkoIrina S.<p>MD, PhD, Associate Professor, Chair of Therapy, Faculty of Internship and Postgraduate Training named after A.I. Dyadyk</p>irina.pogorzhel@mail.ruKononenkoLiudmila V.<p>general practitioner</p>milsik666@gmail.comM. Gorky Donetsk National Medical UniversityInstitute of Urgent and Recovery Surgery named after V.K. GusakCenter for Primary Health Care No. 2 (Ambulatory Clinic No. 5)220720225021391481011202130052022Copyright © 2022, Taradin G.G., Kugler T.E., Malovichko I.S., Kononenko L.V.2022<p>Coronavirus infection (COVID-19) is usually characterized by respiratory symptoms, but can have a wide range of clinical manifestations. The growing interest is focusing on the short-term and long-term immune-mediated sequelae triggered by the COVID-19. One of these complications is post-infectious arthritis, classified by some authors as reactive. This paper summarizes and analyzes 25 clinical cases of COVID-19-associated acute arthritis that have been published from January 2020 to November 2021. The mean age of the patients was 46 14 years, with the disease being more prevalent in men than in women. Joint lesions were mono- or polyarticular, with predominant involvement of the joints of the lower extremities. HLA-B27 antigen was determined in 13 of 25 patients and was found in 30% of cases. Like many other viral diseases, the severe acute respiratory syndrome 2 caused by coronavirus can act as a causative agent or a trigger in the development of inflammatory arthritis in predisposed individuals. The post-infectious arthritis should be differentiated from diseases that can manifest with a similar clinical presentation, which requires a complex of laboratory and instrumental studies. Non-steroidal anti-inflammatory drugs and glucocorticosteroids are successfully used in the treatment. The number of cases of post-COVID-19-arthritis is increasing, which urges further studies of its pathophysiology, diagnosis and treatment regimens.</p>COVID-19SARS-CoV-2post-infectious arthritisacute arthritisspondyloarthritisrheumatic diseasesmolecular mimicryCOVID-19SARS-CoV-2постинфекционный артритострый артритспондилоартритревматические заболеваниямолекулярная мимикрия[World Health Organization. WHO Coronavirus (COVID-19) Dashboard [Internet]. Available from: https://covid19.who.int/.][Zeidler H. Post-COVID-19-Arthritis. Manifestation unter dem klinischen Bild einer reaktiven Arthritis [Post-Corona-Virus-Disease-19 arthritis. Manifestation under the clinical picture of a reactive arthritis]. Z Rheumatol. 2021;80(6):555–558. German. doi: 10.1007/s00393-021-01045-9.][Ahmed S, Zimba O, Gasparyan AY. COVID-19 and the clinical course of rheumatic manifestations. Clin Rheumatol. 2021;40(7):2611–2619. doi: 10.1007/s10067-021-05691-x.][Belov BS, Shubin SV, Balabanova RM, Erdes SF. 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