Almanac of Clinical MedicineAlmanac of Clinical MedicineАльманах клинической медицины2072-05052587-9294Moscow Regional Research and Clinical Institute (MONIKI)144310.18786/2072-0505-2021-49-013REVIEW ARTICLEОБЗОРExpression of the immune checkpoint B7-H3 in tumor and its soluble form in serum of patients with bone neoplasmsЭкспрессия контрольной точки иммунитета B7-H3 в опухоли и ее растворимой формы в сыворотке крови больных новообразованиями костейhttps://orcid.org/0000-0002-3898-4127KushlinskiiN. E.КушлинскийН. Е.
Russian Federation

Nikolay E. Kushlinskii - MD, PhD, Professor, Member of Russian Academy of Sciences, Head of Laboratory of Clinical Biochemistry.

24 Kashirskoe shosse, Moscow, 115478.

Tel.: +7 (499) 324 11 59.

Кушлинский Николай Евгеньевич - доктор медицинских наук, профессор, академик РАН, руководитель лаборатории клинической биохимии.

115478, Москва, Каширское шоссе, 24.

Тел.: +7 (499) 324 11 59.

biochimia@yandex.ruhttps://orcid.org/0000-0001-6132-9924KovalevaO. V.КовалеваО. В.
Russian Federation

Olga V. Kovaleva - PhD (in Biol.), Senior Research Fellow, Laboratory of Regulation of Cellular and Viral Oncogenes, Research Institute of Carcinogenesis.

24 Kashirskoe shosse, Moscow, 115478.

Ковалева Ольга Владимировна – кандидат биологических наук, старший научный сотрудник лаборатории регуляции клеточных и вирусных онкогенов Научно-исследовательского института канцерогенеза.

115478, Москва, Каширское шоссе, 24.

https://orcid.org/0000-0003-3585-5693AlferovA. A.АлферовА. А.
Russian Federation

Aleksandr A. Alferov - Clinical Pathologist, Laboratory of Clinical Biochemistry.

24 Kashirskoe shosse, Moscow, 115478.

Алферов Александр Андреевич - врач клинической лабораторной диагностики лаборатории клинической биохимии.

115478, Москва, Каширское шоссе, 24.

https://orcid.org/0000-0001-9684-2509KuzminYu. B.КузьминЮ. Б.
Russian Federation

Yurii B. Kuzmin - Research Laboratory Assistant, Laboratory of Clinical Biochemistry.

24 Kashirskoe shosse, Moscow, 115478.

Кузьмин Юрий Борисович - лаборант-исследователь лаборатории клинической биохимии.

115478, Москва, Каширское шоссе, 24.

https://orcid.org/0000-0003-3672-1742SushentsovE. A.СушенцовЕ. А.
Russian Federation

Evgeny A. Sushentsov - MD, PhD, Head of Department of Surgical Treatment Methods No. 14 (Oncoorthopedics).

24 Kashirskoe shosse, Moscow, 115478.

Сушенцов Евгений Александрович – кандидат медицинских наук, заведующий отделением хирургических методов лечения № 14 (онкоортопедии).

115478, Москва, Каширское шоссе, 24.

https://orcid.org/0000-0002-0493-1166StilidiI. S.СтилидиИ. С.
Russian Federation

Ivan S. Stilidi - MD, PhD, Professor, Member of the Russian Academy of Sciences, Director.

24 Kashirskoe shosse, Moscow, 115478.

Стилиди Иван Сократович – доктор медицинских наук, профессор, академик РАН, директор.

115478, Москва, Каширское шоссе, 24.

N.N. Blokhin National Medical Research Center of OncologyНациональный медицинский исследовательский центр онкологии имени Н.Н. Блохина Минздрава России170720214931791900104202101042021Copyright ©; 2021, Kushlinskii N.E., Kovaleva O.V., Alferov A.A., Kuzmin Y.B., Sushentsov E.A., Stilidi I.S.Copyright ©; 2021, Кушлинский Н.Е., Ковалева О.В., Алферов А.А., Кузьмин Ю.Б., Сушенцов Е.А., Стилиди И.С.2021Kushlinskii N.E., Kovaleva O.V., Alferov A.A., Kuzmin Y.B., Sushentsov E.A., Stilidi I.S.Кушлинский Н.Е., Ковалева О.В., Алферов А.А., Кузьмин Ю.Б., Сушенцов Е.А., Стилиди И.С.https://creativecommons.org/licenses/by/4.0https://almclinmed.ru/jour/article/view/1443

B7-H3, also called CD276, is a type I transmembrane glycoprotein that is encoded on human chromosome 15. It was discovered back in 2001. The original study described it as a positive co-stimulant, as it can stimulate T-cell response and IFN-y production. However, recent researches have shown that B7-H3 is involved in T-cell inhibition. A B7-H3 receptor has not been yet identified, and this may explain the complex immunomodulatory activity of B7-H3, as it can have more than one binding partner with different functions. Expression of the B7-H3 protein has been found on activated immune cells such as T-cells, NK cells and antigen presenting cells. Interestingly, it is overexpressed in a wide range of tumor cells and is associated with disease progression and outcome. The soluble form of this protein is also of particular interest. Increased sB7-H3 levels in the plasma of bone tumor patients might be their important diagnostic criterion.

B7-H3, также называемый CD276, представляет собой трансмембранный гликопротеин типа I, который кодируется на хромосоме 15 человека. Он был открыт еще в 2001 г. Первоначальное исследование описало его как положительный костимулятор вследствие способности стимулировать Т-клеточный ответ и продукцию IFN-Y. Однако недавние исследования показали, что B7-H3 участвует в ингибировании Т-клеток. Рецептор для B7-H3 еще не идентифицирован. Это объясняет сложную иммуномодулирующую активность B7-H3, который может иметь более одного партнера по связыванию с различными функциями. Экспрессию белка B7-H3 наблюдали на активированных иммунных клетках, таких как Т-клетки, NK-клетки и антигенпрезентирующие клетки. Интересно, что он гиперэкспресси-рован в широком спектре опухолевых клеток и связан с прогрессией заболевания и прогнозом. Особый интерес представляет также растворимая форма данного белка. Повышение содержания sB7-H3 в плазме крови больных опухолями костей может оказаться важным диагностическим критерием.

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