Almanac of Clinical MedicineAlmanac of Clinical MedicineАльманах клинической медицины2072-05052587-9294Moscow Regional Research and Clinical Institute (MONIKI)13910.18786/2072-0505-2014-32-80-88REVIEW ARTICLEОБЗОРEFFICIENCY AND SAFETY OF THE ORAL HYPOGLYCAEMIC AGENTS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND CARDIOVASCULAR DISEASESЭФФЕКТИВНОСТЬ И БЕЗОПАСНОСТЬ ПЕРОРАЛЬНЫХ САХАРОСНИЖАЮЩИХ ПРЕПАРАТОВ У БОЛЬНЫХ САХАРНЫМ ДИАБЕТОМ 2-ГО ТИПА И СЕРДЕЧНО-СОСУДИСТЫМИ ЗАБОЛЕВАНИЯМИMakeevaE. I.МакееваЕ. И.
Russian Federation

postgraduate student of the Angiology Department, Institute of Clinical Cardiology, RCRPC

аспирант отдела ангиологии Института клинической кардиологии, РКНПК

lenokmma@mail.ruOskolаE. V.ОсколаЕ. В.
Russian Federation

postgraduate student of the Angiology Department, Institute of Clinical Cardiology, RCRPC

аспирант отдела ангиологии Института клинической кардиологии, РКНПК

ShubinаA. T.ШубинаА. Т.
Russian Federation

MD, PhD, researcher of the Angiology Department, Institute of Clinical Cardiology, RCRPC

канд. мед. наук, науч. сотр. отдела ангиологии Института клинической кардиологии, РКНПК.

KarpovYu. A.КарповЮ. А.
Russian Federation

MD, PhD, Professor, Head of the Angiology Department, Institute of Clinical Cardiology; the First Deputy Director General, RCRPC; Deputy Director General for science, RCRPC

д-р мед. наук, профессор, руководитель отдела ангиологии Института клинической кардиологии, РКНПК; первый зам. ген. директора РКНПК, зам. ген. директора по науке РКНПК

Russian Cardiology Research and Production Complex (RCRPC)ФГБУ «Российский кардиологический научно-производственный комплекс» Минздрава России (РКНПК)15а 3-Cherepkovskaya ul., Moscow, 121552, Russian Federation121552, г. Москва, ул. 3-я Черепковская, 15а, Российская Федерация150520143280881302201613022016Copyright ©; 2014, Makeeva E.I., Oskolа E.V., Shubinа A.T., Karpov Y.A.Copyright ©; 2014, Макеева Е.И., Оскола Е.В., Шубина А.Т., Карпов Ю.А.2014Makeeva E.I., Oskolа E.V., Shubinа A.T., Karpov Y.A.Макеева Е.И., Оскола Е.В., Шубина А.Т., Карпов Ю.А.https://creativecommons.org/licenses/by/4.0https://almclinmed.ru/jour/article/view/139

Diabetes mellitus is an important problem for every country in the world. The type 2 diabetes mellitus (T2DM) enables development of atherosclerosis and increases the risk of cardiovascular disease. Blood glucose control has been shown to be the most relevant factor for the prevention of the cardiovascular complications in T2DM patients. The cardiovascular protective effect of oral antidiabetic drugs is still under investigation. In this respect, we concern to be prospective the innovative oral hypoglycaemic agents such as the dipeptidyl peptidase-4 inhibitors.

Сахарный диабет является важной проблемой здравоохранения во всех странах мира. Наличие сахарного диабета 2-го типа (СД2) способствует развитию атеросклероза и повышает риск сердечно-сосудистых осложнений (ССО). Коррекция уровня гликемии служит важнейшим условием профилактики сосудистых осложнений у больных СД2. Возможности снижения риска ССО на фоне терапии пероральными сахароснижающими препаратами продолжают изучаться. В этом отношении перспективны представители инновационных классов пероральных сахароснижающих препаратов, в том числе ингибиторы дипептидилпептидазы-4.

type 2 diabetes mellitusdipeptidyl peptidase-4 inhibitorscardiovascular complicationsсахарный диабет 2-го типаингибиторы дипептидилпептидазы-4сердечно-сосудистые осложнения1. IDF Diabetes Atlas. 6th edition. International Diabetes Federation; 2013. Available from: URL: http://www.idf.org/diabetesatlas2. Дедов ИИ, Шестакова МВ, ред. Алгоритмы специализированной медицинской помощи больным сахарным диабетом. 6-й выпуск. М.: Информполиграф; 2013. (Dedov II, Shestakova MV. [Algorithms of the specialized medical aid for diabetes mellitus patients]. 6th edition. Moscow: Inform-poligraf; 2013. Russian).3. Дедов ИИ, Шестакова МВ, Аметов АС, Анциферов МБ, Галстян ГР, Майоров АЮ, Мкртумян АМ, Петунина НА, Сухарева ОЮ. Консенсус совета экспертов Российской ассоциации эндокринологов (РАЭ) по инициации и интенсификации сахароснижающей терапии сахарного диабета 2 типа. Сахарный диабет. 2011; (4):6-17. 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