Almanac of Clinical MedicineAlmanac of Clinical MedicineАльманах клинической медицины2072-05052587-9294Moscow Regional Research and Clinical Institute (MONIKI)135810.18786/2072-0505-2020-48-050CLINICAL GUIDELINESКЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИEarly administration of genetically engineered biological agents for immune-mediated inflammatory diseases: opportunities and prospects. An experts’ opinionРаннее назначение генно-инженерных биологических препаратов при иммуновоспалительных заболеваниях: возможности и перспективы. Позиция экспертовhttps://orcid.org/0000-0001-7069-2725AbdulganievaD. I.АбдулганиеваД. И.
Russian Federation

Diana I. Abdulganieva – MD, PhD, Professor, Head of Chair of Hospital Therapy 

49 Butlerova ul., Kazan, Republic of Tatarstan, 420012

Абдулганиева Диана Ильдаровна – доктор медицинских наук, профессор, заведующая кафедрой госпитальной терапии

420012, Республика Татарстан, г. Казань, ул. Бутлерова, 49

diana_s@mail.ruhttps://orcid.org/0000-0002-1450-4942BakulevA. L.БакулевА. Л.
Russian Federation

Andrey L. Bakulev – MD, PhD, Professor, Chair of Dermatovenereology and Cosmetology 

112 Bol'shaya Kazach'ya ul., Saratov, Saratovskaya oblast', Privolzhskiy federal'nyy okrug, 410012

Бакулев Андрей Леонидович – доктор медицинских наук, профессор кафедры дерматовенерологии и косметологии

410012, Приволжский федеральный округ, Саратовская область, г. Саратов, ул. Большая Казачья, 112

https://orcid.org/0000-0003-4523-3337BelousovaE. A.БелоусоваЕ. А.
Russian Federation

Elena A. Belousova – MD, PhD, Professor, Head of Department of Gastroenterology; Head of Chair of Gastroenterology, Postgraduate Training Faculty 

61/2 Shchepkina ul., Moscow, 129110

Белоусова Елена Александровна – доктор медицинских наук, профессор, руководитель отделения гастроэнтерологии, заведующая кафедрой гастроэнтерологии факультета усовершенствования врачей

129110, г. Москва, ул. Щепкина, 61/2–9

eabelous@yandex.ruhttps://orcid.org/0000-0003-3115-1787VeselovA. V.ВеселовА. В.
Russian Federation

Alexey V. Veselov – Head of Department of Organization, Education and Development of Coloproctological Service 

2 Salyama Adilya ul., Moscow, 123423

Веселов Алексей Викторович – руководитель отдела по организационной, образовательной работе и развитию колопроктологической службы

123423, г. Москва, ул. Саляма Адиля, 2

https://orcid.org/0000-0003-0579-1131KorotaevaT. V.КоротаеваТ. В.
Russian Federation

Tatiana V. Korotaeva – MD, PhD, Leading Research Fellow, Laboratory of Innovative Methods for Diagnosis and Treatment of Psoriatic Arthritis 

34A Kashirskoe shosse, Moscow, 115522

Коротаева Татьяна Викторовна – доктор медицинских наук, ведущий научный сотрудник лаборатории диагностики и инновационных методов лечения псориатического артрита

115522, г. Москва, Каширское шоссе, 34А

tatianakorotaeva@gmail.comhttps://orcid.org/0000-0002-6068-3080LilaA. M.ЛилаА. М.
Russian Federation

Aleksander M. Lila – MD, PhD, Professor, Director Research Institute of Rheumatology named after V.A. Nasonova; Head of Chair of Rheumatology Russian Medical Academy of Continuous Professional Education

34A Kashirskoe shosse, Moscow, 115522; 2/1–1 Barrikadnaya ul., Moscow, 125993

Лила Александр Михайлович – доктор медицинских наук, профессор, директор ФГБНУ «Научно-исследовательский институт ревматологии имени В.А. Насоновой»; заведующий кафедрой ревматологии ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России

115522, г. Москва, Каширское шоссе, 34А;125993, г. Москва, ул. Баррикадная, 2/1–1

https://orcid.org/0000-0001-6875-4552LoginovaE. Yu.ЛогиноваЕ. Ю.
Russian Federation

Elena Yu. Loginova – MD, PhD, Senior Research Fellow, Laboratory of Spondylarthritis and Psoriatic Arthritis 

34A Kashirskoe shosse, Moscow, 115522

Логинова Елена Юрьевна – кандидат медицинских наук, ст. науч. сотр. лаборатории спондилоартритов и псориатического артрита

115522, г. Москва, Каширское шоссе, 34А

https://orcid.org/0000-0001-7610-6061SokolovskiyE. V.СоколовскийЕ. В.
Russian Federation

Evgeny V. Sokolovskiy – MD, PhD, Professor, Head of Chair and Clinic of Dermatovenereology 

6–8 L'va Tolstogo ul., Saint Petersburg, 197022

Соколовский Евгений Владиславович – доктор медицинских наук, профессор, заведующий кафедрой дерматовенерологии с клиникой

197022, г. Санкт-Петербург, ул. Льва Толстого, 6–8

https://orcid.org/0000-0001-8670-7223KhobeyshM. M.ХобейшМ. М.
Russian Federation

Marianna M. Khobeysh – MD, PhD, Associate Professor, Chair and Clinic of Dermatovenereology 

6–8 L'va Tolstogo ul., Saint Petersburg, 197022

Хобейш Марианна Михайловна – кандидат медицинских наук, доцент кафедры дерматовенерологии с клиникой

197022, г. Санкт-Петербург, ул. Льва Толстого, 6–8

mkhobeysh@yandex.ruhttps://orcid.org/0000-0003-1172-6221ShapinaM. V.ШапинаМ. В.
Russian Federation

Marina V. Shapina – MD, PhD, Head of Department of Research in Inflammatory and Functional Bowel Disorders 

2 Salyama Adilya ul., Moscow, 123423

Шапина Марина Владимировна – кандидат медицинских наук, руководитель отдела по изучению воспалительных и функциональных заболеваний кишечника

123423, г. Москва, ул. Саляма Адиля, 2

ShchukinaO. B.ЩукинаО. Б.
Russian Federation

Oksana B. Shchukina – MD, PhD, Head of Center of Inflammatory Bowel Disease 

3 Dinamo prospekt, Saint Petersburg, 197110

Щукина Оксана Борисовна – доктор медицинских наук, руководитель Центра воспалительных заболеваний кишечника

197110, г. Санкт-Петербург, пр-т Динамо, 3

Kazan Medical UniversityФГБОУ ВО «Казанский государственный медицинский университет» Минздрава РоссииV.I. Razumovsky Saratov State Medical UniversityФГБОУ ВО «Саратовский государственный медицинский университет имени В.И. Разумовского» Минздрава РоссииMoscow Regional Research and Clinical Institute (MONIKI)ГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»National Medical Research Centre for Coloproctology named after A.N. RyzhikhФГБУ «Национальный медицинский исследовательский центр колопроктологии имени А.Н. Рыжих» Минздрава РоссииResearch Institute of Rheumatology named after V.A. NasonovaФГБНУ «Научно-исследовательский институт ревматологии имени В.А. Насоновой»Russian Medical Academy of Continuous Professional EducationФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииAcademician I.P. Pavlov First St. Petersburg State Medical UniversityФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова» Минздрава РоссииCity Clinical Hospital No. 31 (Saint Petersburg)Санкт-Петербургское ГУЗ «Городская клиническая больница № 31»291220204864224361510202015102020Copyright ©; 2020, Abdulganieva D.I., Bakulev A.L., Belousova E.A., Veselov A.V., Korotaeva T.V., Lila A.M., Loginova E.Y., Sokolovskiy E.V., Khobeysh M.M., Shapina M.V., Shchukina O.B.Copyright ©; 2020, Абдулганиева Д.И., Бакулев А.Л., Белоусова Е.А., Веселов А.В., Коротаева Т.В., Лила А.М., Логинова Е.Ю., Соколовский Е.В., Хобейш М.М., Шапина М.В., Щукина О.Б.2020Abdulganieva D.I., Bakulev A.L., Belousova E.A., Veselov A.V., Korotaeva T.V., Lila A.M., Loginova E.Y., Sokolovskiy E.V., Khobeysh M.M., Shapina M.V., Shchukina O.B.Абдулганиева Д.И., Бакулев А.Л., Белоусова Е.А., Веселов А.В., Коротаева Т.В., Лила А.М., Логинова Е.Ю., Соколовский Е.В., Хобейш М.М., Шапина М.В., Щукина О.Б.https://creativecommons.org/licenses/by/4.0https://almclinmed.ru/jour/article/view/1358

Psoriasis (Ps), psoriatic arthritis (PsA), and inflammatory bowel diseases (IBDs) are characterized by a  progressive course and commonly result in disability. Therefore, their early diagnosis with the assessment of a  clinical phenotype and unfavorable prognostic factors and the timely initiation of therapy are important. The paper provides the expert consensus on the definition of the early stage of Ps, PsA, and IBDs, their treatment goals and main unfavorable prognostic factors. It also gives the rationale for the early use of biological agents in patients with immune-mediated inflammatory diseases.

Псориаз (Пс), псориатический артрит (ПсА) и  воспалительные заболевания кишечника (ВЗК) характеризуются прогрессирующим течением и  нередко приводят к  инвалидизации, поэтому важными задачами становятся их ранняя диагностика с  оценкой клинического фенотипа и  факторов неблагоприятного прогноза и  своевременное начало терапии. В  статье приводятся согласованная позиция экспертов по определению ранней стадии Пс, ПсА и  ВЗК, цели терапии и  основные факторы неблагоприятного прогноза течения этих заболеваний, представлено обоснование раннего применения генно-инженерных биологических препаратов у  пациентов с  иммуновоспалительной патологией.

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